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KMID : 0363220090470070850
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Korean Journal of Dermatology
2009 Volume.47 No. 7 p.850 ~ p.854
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Application of the QuantiFERON(R)-TB Gold Test in Two Cases of Erythema Induratum of Bazin
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Ji Jae-Hong
Choi Eung-Ho
Park Hwa-Young
Lee Yoon-hee
Lee Hae-Jin
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Abstract
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Erythema induratum of Bazin is a chronic, nodular subcutaneous eruption usually occurring on the lower legs of young women. Erythema induratum of Bazin hasbeen regarded as a tuberculide, a hypersensitivity response to Mycobacterium tuberculosis. The pathogenesis of erythema induratum of Bazin associated with tuberculosis is still debatable because mycobacteria cannot be cultured from the skin lesions. QuantiFERONⓡ-TB Gold test detects INF-γ released by T cells in response to Mycobacterium tuberculosis-specific antigens, which offers an improved diagnostic test of latent tuberculosis infection. We experienced two cases of erythema induratum of Bazin, which showed normal chest X-ray and negative TB-PCR. However the QuantiFERONⓡ-TB Gold test was positive which led us to a diagnosis of latent tuberculosis infection. Both patients were treated with anti-tuberculosis medications, which was followed by successful resolution of the skin lesions. Therefore, we report the application of the QuantiFERONⓡ-TB Gold test for the confirmation of latent tuberculosis infection in erythema induratum of Bazin patients.
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KEYWORD
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Erythema induratum of Bazin, Interferon-γ, Latent tuberculosis infection, QuantiFERONⓡ-TB Gold test
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